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Moderna正研发一款能预防新冠病毒和流感的单剂疫苗

Moderna正研发一款能预防新冠病毒和流感的单剂疫苗

Sy Mukherjee 2021-05-02
该公司的首席执行官表示,mRNA平台的延展性使其更易对抗新出现的新冠病毒变异株和病原体等。

抵御新冠病毒入侵,有效预防季节性流感。

这是Moderna公司的首席执行官斯特凡内·班塞尔为公司设立的目标。该公司是成功研发出有效新冠疫苗的开拓者之一。4月27日,他在《财富》2021虚拟头脑风暴健康大会的一次讨论中提到了这个目标。

班塞尔表示,公司希望利用其信使核糖核酸(mRNA)技术研发一款能够同时灭杀几种致病菌的疫苗,因为mRNA技术对抗变异毒株的效力更强。

他在接受《财富》杂志的主编黎克腾采访时称:“我们的目标是研发出一款高效流感疫苗,然后将其与新冠变异毒株相融合。所以在同一针剂中接种了这款高效流感疫苗,就可以对抗某一特定年份出现的相应变种病毒,人们能够在CVS药店或者全科医生那里接种一剂疫苗,到那时就完全不用再担心感染流感或新冠病毒。”

基于mRNA的治疗方法从更广阔的角度考虑疫苗的生物过程。这类技术仅依靠对人体细胞进行编码来发挥完全合成药物通常具有的作用,而不是在培养皿中制造大量抗原。在头脑风暴健康大会上,班塞尔将其比作对身体进行编程。一个程序就有无限潜能。

他说:“mRNA就是一个软件。所以我们清楚该如何通过技术让几种mRNA对抗不同类型的流感病毒,并将可以对抗不同新冠变异毒株的几种mRNA融进一剂疫苗中。所以你只需接种一次,就能够获得免疫保护。”

Moderna公司还有更远大的愿景。就在一年前,生物技术领域的许多投资者还对利用mRNA技术进行治疗或研发疫苗的想法不屑一顾。当时人们认为,这一新兴领域简直是不自量力。但现在已经今时不同往日了。

该公司正在致力于研发从预防寨卡病毒(Zika)的传染病药物到癌症疫苗等各种产品。正如班塞尔所言,mRNA平台的延展性使其更易对抗新出现的新冠病毒变异株和病原体等。(财富中文网)

翻译:郝秀

审校:汪皓

抵御新冠病毒入侵,有效预防季节性流感。

这是Moderna公司的首席执行官斯特凡内·班塞尔为公司设立的目标。该公司是成功研发出有效新冠疫苗的开拓者之一。4月27日,他在《财富》2021虚拟头脑风暴健康大会的一次讨论中提到了这个目标。

班塞尔表示,公司希望利用其信使核糖核酸(mRNA)技术研发一款能够同时灭杀几种致病菌的疫苗,因为mRNA技术对抗变异毒株的效力更强。

他在接受《财富》杂志的主编黎克腾采访时称:“我们的目标是研发出一款高效流感疫苗,然后将其与新冠变异毒株相融合。所以在同一针剂中接种了这款高效流感疫苗,就可以对抗某一特定年份出现的相应变种病毒,人们能够在CVS药店或者全科医生那里接种一剂疫苗,到那时就完全不用再担心感染流感或新冠病毒。”

基于mRNA的治疗方法从更广阔的角度考虑疫苗的生物过程。这类技术仅依靠对人体细胞进行编码来发挥完全合成药物通常具有的作用,而不是在培养皿中制造大量抗原。在头脑风暴健康大会上,班塞尔将其比作对身体进行编程。一个程序就有无限潜能。

他说:“mRNA就是一个软件。所以我们清楚该如何通过技术让几种mRNA对抗不同类型的流感病毒,并将可以对抗不同新冠变异毒株的几种mRNA融进一剂疫苗中。所以你只需接种一次,就能够获得免疫保护。”

Moderna公司还有更远大的愿景。就在一年前,生物技术领域的许多投资者还对利用mRNA技术进行治疗或研发疫苗的想法不屑一顾。当时人们认为,这一新兴领域简直是不自量力。但现在已经今时不同往日了。

该公司正在致力于研发从预防寨卡病毒(Zika)的传染病药物到癌症疫苗等各种产品。正如班塞尔所言,mRNA平台的延展性使其更易对抗新出现的新冠病毒变异株和病原体等。(财富中文网)

翻译:郝秀

审校:汪皓

Come for the COVID immunization. Stay for protection against the seasonal flu.

That's the goal that Moderna CEO Stéphane Bancel has set out for his company, one of the pioneering developers of effective COVID vaccines, which he shared during a discussion at Fortune's 2021 virtual Brainstorm Health conference on April 27.

Bancel said the company hopes to use its messenger RNA (mRNA)-based technology, which can be more adaptable to changing viral strains, to knock out several pathogenic birds with one stone.

"Our vision is to develop a high efficacy flu vaccine, and then merge it with COVID variables," he said during an interview with Fortune editor-in-chief Clifton Leaf. "So in the same single shot, you get a high efficacy flu vaccine, the appropriate virus variant for that given year, and you walk into your your CVS or go to your [general practitioner], you get one dose and you're all set for flu and for COVID."

mRNA-based therapeutics take the biological process back by one step. Rather than manufacture massive amounts of antigens in petri dishes, these sorts of technologies simply rely on coding your actual cells to perform the functions that a fully-constructed drug usually would. At Brainstorm Health, Bancel likened it to programming your body. And a program has boundless potential.

"mRNA is a piece of software," he said. "So we know how to technically put several mRNA to deal with several strains of flu and several mRNA dealing with several strains of COVID variants into a single dose. So you just need one shot, and you'll be protected."

Moderna has far wider ambitions. Just one year ago, many in the biotechnology investor class scoffed at the thought of an mRNA-based therapeutic or vaccine. The eyes of that nascent industry were too big for its stomach, the thinking went. How times have changed.

The firm is working on products ranging from infectious disease drugs to protect against Zika to cancer vaccines. And the malleability of the mRNA platform, as Bancel said, could make it far easier to deal with emerging variant strains of the coronavirus and pathogens beyond.

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